KPNA4 polyclonal antibody
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More Files
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Western Blot
The KPNA4 polyclonal antibody (Cat # PAB3804) is used in Western blot to detect KPNA4 in Hela (left) , mouse brain (middle) , and HepG2 (right) cell and tissue lysates.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of KPNA4.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human KPNA4.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
The KPNA4 polyclonal antibody (Cat # PAB3804) is used in Western blot to detect KPNA4 in Hela (left) , mouse brain (middle) , and HepG2 (right) cell and tissue lysates. -
Gene Info — KPNA4
Entrez GeneID
3840Protein Accession#
NP_002259;O00629Gene Name
KPNA4
Gene Alias
IPOA3, MGC12217, MGC26703, QIP1, SRP3
Gene Description
karyopherin alpha 4 (importin alpha 3)
Omim ID
602970Gene Ontology
HyperlinkGene Summary
The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen. [provided by RefSeq
Other Designations
importin alpha 3|importin-alpha-Q1|karyopherin alpha 4
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Interactome
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Publication Reference
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Reassessment of the roles of integrase and the central DNA flap in human immunodeficiency virus type 1 nuclear import.
Dvorin JD, Bell P, Maul GG, Yamashita M, Emerman M, Malim MH.
Journal of Virology 2002 Dec; 76(23):12087.
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Nuclear localization of human immunodeficiency virus type 1 preintegration complexes (PICs): V165A and R166A are pleiotropic integrase mutants primarily defective for integration, not PIC nuclear import.
Limon A, Devroe E, Lu R, Ghory HZ, Silver PA, Engelman A.
Journal of Virology 2002 Nov; 76(21):10598.
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Reassessment of the roles of integrase and the central DNA flap in human immunodeficiency virus type 1 nuclear import.
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