RUVBL2 polyclonal antibody
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More Files
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Western Blot
The RUVBL2 polyclonal antibody (Cat # PAB3727) is used in Western blot to detect RUVBL2 in mouse kidney (left) and SK-BR-3 (right) tissue/cell line lysates.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of RUVBL2.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human RUVBL2.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
The RUVBL2 polyclonal antibody (Cat # PAB3727) is used in Western blot to detect RUVBL2 in mouse kidney (left) and SK-BR-3 (right) tissue/cell line lysates. -
Gene Info — RUVBL2
Entrez GeneID
10856Protein Accession#
NP_006657;Q6FIB9Gene Name
RUVBL2
Gene Alias
CGI-46, ECP51, INO80J, REPTIN, RVB2, TIH2, TIP48, TIP49B
Gene Description
RuvB-like 2 (E. coli)
Omim ID
604788Gene Ontology
HyperlinkGene Summary
This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this gene product has both ATPase and DNA helicase activities. This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation. [provided by RefSeq
Other Designations
INO80 complex subunit J|Reptin52|RuvB (E coli homolog)-like 2|RuvB-like 2|TBP-interacting protein, 48-KD|erythrocyte cytosolic protein, 51-KD
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Interactome
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Disease
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Publication Reference
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Pontin52 and reptin52 function as antagonistic regulators of beta-catenin signalling activity.
Bauer A, Chauvet S, Huber O, Usseglio F, Rothbacher U, Aragnol D, Kemler R, Pradel J.
The EMBO Journal 2000 Nov; 19(22):6121.
Application：IP-WB, WB-Tr, Human, HEK 293 cells.
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Human TIP49b/RUVBL2 gene: genomic structure, expression pattern, physical link to the human CGB/LHB gene cluster on chromosome 19q13.3.
Parfait B, Giovangrandi Y, Asheuer M, Laurendeau I, Olivi M, Vodovar N, Vidaud D, Vidaud M, Bieche I.
Annales de Génétique 2000 Apr; 43(2):69.
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An ATPase/helicase complex is an essential cofactor for oncogenic transformation by c-Myc.
Wood MA, McMahon SB, Cole MD.
Molecular Cell 2000 Feb; 5(2):321.
Application：WB, Human, HEK 293 cells.
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Pontin52 and reptin52 function as antagonistic regulators of beta-catenin signalling activity.
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