BMP2K polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
The BMP2K polyclonal antibody (Cat # PAB3681) is used in Western blot to detect BMP2K in mouse liver tissue lysate.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with BMP2K polyclonal antibody (Cat # PAB3681) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of BMP2K.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to internal region of human BMP2K.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein G purification
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-100)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
The BMP2K polyclonal antibody (Cat # PAB3681) is used in Western blot to detect BMP2K in mouse liver tissue lysate.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with BMP2K polyclonal antibody (Cat # PAB3681) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma. -
Gene Info — BMP2K
Entrez GeneID
55589Protein Accession#
NP_942595;Q9NSY1Gene Name
BMP2K
Gene Alias
BIKE, DKFZp434K0614, DKFZp434P0116, HRIHFB2017
Gene Description
BMP2 inducible kinase
Gene Ontology
HyperlinkGene Summary
This gene is the human homolog of mouse BMP-2-inducible kinase. Bone morphogenic proteins (BMPs) play a key role in skeletal development and patterning. Expression of the mouse gene is increased during BMP-2 induced differentiation and the gene product is a putative serine/threonine protein kinase containing a nuclear localization signal. Therefore, the protein encoded by this human homolog is thought to be a protein kinase with a putative regulatory role in attenuating the program of osteoblast differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
BMP-2 inducible kinase
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Interactome
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Disease
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Publication Reference
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Cloning and characterization of a novel protein kinase that impairs osteoblast differentiation in vitro.
Kearns AE, Donohue MM, Sanyal B, Demay MB.
The Journal of Biological Chemistry 2001 Nov; 276(45):42213.
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BMP signaling pathways in cartilage and bone formation.
Hoffmann A, Gross G.
Crit Rev Eukaryot Gene Expr 2001 Jan; 11(1-3).
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Cloning and characterization of a novel protein kinase that impairs osteoblast differentiation in vitro.
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