PDGFB polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PDGFB.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human PDGFB.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Immunofluorescence (1:10-50)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
The PDGFB polyclonal antibody (Cat # PAB3679) is used in Western blot to detect PDGFC in A-375 cell lysate.Immunofluorescence
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Gene Info — PDGFB
Entrez GeneID
5155Protein Accession#
PDGB_HUMANGene Name
PDGFB
Gene Alias
FLJ12858, PDGF2, SIS, SSV, c-sis
Gene Description
platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
Omim ID
190040Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq
Other Designations
PDGF, B chain|Platelet-derived growth factor, beta polypeptide (oncogene SIS)|becaplermin|oncogene SIS|platelet-derived growth factor 2|platelet-derived growth factor beta|platelet-derived growth factor, B chain|v-sis platelet-derived growth factor beta p
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Interactome
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Pathway
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Disease
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Publication Reference
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Kinetics control preferential heterodimer formation of platelet-derived growth factor from unfolded A- and B-chains.
Muller C, Richter S, Rinas U.
The Journal of Biological Chemistry 2003 May; 278(20):18330.
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Fusion of COL1A1 exon 29 with PDGFB exon 2 in a der(22)t(17;22) in a pediatric giant cell fibroblastoma with a pigmented Bednar tumor component. Evidence for age-related chromosomal pattern in dermatofibrosarcoma protuberans and related tumors.
Maire G, Martin L, Michalak-Provost S, Gattas GJ, Turc-Carel C, Lorette G, Pedeutour F.
Cancer Genetics and Cytogenetics 2002 Apr; 134(2):156.
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Kinetics control preferential heterodimer formation of platelet-derived growth factor from unfolded A- and B-chains.
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