GJA8 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of GJA8.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human GJA8.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein G purification
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-100)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of mouse kidney tissue lysate (35 ug/lane) with GJA8 polyclonal antibody (Cat # PAB3595).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with GJA8 polyclonal antibody (Cat # PAB3595) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma. -
Gene Info — GJA8
Entrez GeneID
2703Protein Accession#
P48165Gene Name
GJA8
Gene Alias
CAE, CAE1, CX50, CZP1, MP70
Gene Description
gap junction protein, alpha 8, 50kDa
Gene Ontology
HyperlinkGene Summary
alpha 8
Other Designations
OTTHUMP00000025757|cell surface glycoprotein|connexin 50|gap junction membrane channel protein alpha-8
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Interactome
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Disease
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Publication Reference
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A missense mutation in the human connexin50 gene (GJA8) underlies autosomal dominant "zonular pulverulent" cataract, on chromosome 1q.
Shiels A, Mackay D, Ionides A, Berry V, Moore A, Bhattacharya S.
American Journal of Human Genetics 1998 Mar; 62(3):526.
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The human lens intrinsic membrane protein MP70 (Cx50) gene: clonal analysis and chromosome mapping.
Church RL, Wang JH, Steele E.
Current Eye Research 1995 Oct; 14(10):979.
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A missense mutation in the human connexin50 gene (GJA8) underlies autosomal dominant "zonular pulverulent" cataract, on chromosome 1q.
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