GJB5 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of MDA-MB-231 cell lysate (35 ug/lane) with GJB5 polyclonal antibody (Cat # PAB3590).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with GJB5 polyclonal antibody (Cat # PAB3590) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of GJB5.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to internal region of human GJB5.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-100)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of MDA-MB-231 cell lysate (35 ug/lane) with GJB5 polyclonal antibody (Cat # PAB3590).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with GJB5 polyclonal antibody (Cat # PAB3590) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma. -
Gene Info — GJB5
Entrez GeneID
2709Protein Accession#
NP_005259;O95377Gene Name
GJB5
Gene Alias
CX31.1
Gene Description
gap junction protein, beta 5, 31.1kDa
Omim ID
604493Gene Ontology
HyperlinkGene Summary
Gap junctions are conduits that allow the direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, and thereby mediate intercellular metabolic and electrical communication. Gap junction channels consist of connexin protein subunits, which are encoded by a multigene family.[supplied by OMIM
Other Designations
OTTHUMP00000004186|connexin 31.1|gap junction protein, beta 5 (connexin 31.1)
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Interactome
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Disease
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Publication Reference
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Mutations in the human connexin gene GJB3 cause erythrokeratodermia variabilis.
Richard G, Smith LE, Bailey RA, Itin P, Hohl D, Epstein EH Jr, DiGiovanna JJ, Compton JG, Bale SJ.
Nature Genetics 1998 Dec; 20(4):366.
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Mutations in the human connexin gene GJB3 cause erythrokeratodermia variabilis.
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