GRK7 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of GRK7.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human GRK7.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-100)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of GRK7 polyclonal antibody (Cat # PAB3452) in HepG2 cell line lysates (35 ug/lane). GRK7 (arrow) was detected using the purified polyclonal antibody (1 : 60 dilution).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with GRK7 polyclonal antibody (Cat # PAB3452) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma. -
Gene Info — GRK7
Entrez GeneID
131890Protein Accession#
Q8WTQ7Gene Name
GRK7
Gene Alias
GPRK7
Gene Description
G protein-coupled receptor kinase 7
Omim ID
606987Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. It is specifically expressed in the retina and the encoded protein has been shown to phosphorylate cone opsins and initiate their deactivation. [provided by RefSeq
Other Designations
G-protein-coupled receptor kinase 7
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Pathway
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Disease
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Publication Reference
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Characterization of human GRK7 as a potential cone opsin kinase.
Chen CK, Zhang K, Church-Kopish J, Huang W, Zhang H, Chen YJ, Frederick JM, Baehr W.
Molecular Vision 2001 Dec; 7:305.
Application:IF, IHC, WB-Ti, Bovine, Chicken, Human, Mouse, Pig, Rat, Pancreas, Retinas.
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Species-specific differences in expression of G-protein-coupled receptor kinase (GRK) 7 and GRK1 in mammalian cone photoreceptor cells: implications for cone cell phototransduction.
Weiss ER, Ducceschi MH, Horner TJ, Li A, Craft CM, Osawa S.
Journal of Neuroscience 2001 Dec; 21(23):9175.
Application:IHC-Fr, WB-Tr, Human, Dog, Monkey, Mouse, Pig, HEK 293 cells, Eyes.
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Characterization of human GRK7 as a potential cone opsin kinase.
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