YES1 polyclonal antibody
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More Files
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Western Blot (Tissue lysate)
Western blot analysis of YES1 polyclonal antibody (Cat # PAB3445) in mouse kidney tissue lysate. YES1 (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with YES1 polyclonal antibody (Cat # PAB3445) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of YES1.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human YES1.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein G purification
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-100)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of YES1 polyclonal antibody (Cat # PAB3445) in mouse kidney tissue lysate. YES1 (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with YES1 polyclonal antibody (Cat # PAB3445) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma. -
Gene Info — YES1
Entrez GeneID
7525Protein Accession#
P07947Gene Name
YES1
Gene Alias
HsT441, P61-YES, Yes, c-yes
Gene Description
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
Omim ID
164880Gene Ontology
HyperlinkGene Summary
This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. [provided by RefSeq
Other Designations
OTTHUMP00000162194|Yamaguchi sarcoma oncogene|cellular yes-1 protein|proto-oncogene tyrosine-protein kinase YES|viral oncogene yes-1 homolog 1
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Interactome
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Pathway
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Disease
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Publication Reference
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QM, a putative tumor suppressor, regulates proto-oncogene c-yes.
Oh HS, Kwon H, Sun SK, Yang CH.
The Journal of Biological Chemistry 2002 Sep; 277(39):36489.
Application：IF, IP-WB, WB-Tr, Human, BOSC 23, AGS, HeLa, HepG2, HCT116, MCF-7 cells.
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Regulation of the human sperm tyrosine kinase c-yes. Activation by cyclic adenosine 3',5'-monophosphate and inhibition by Ca(2+).
Leclerc P, Goupil S.
Biology of Reproduction 2002 Jul; 67(1):301.
Application：IF, WB-Ce, Human, Sperm.
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Chromosomal reassignment: YACs containing both YES1 and thymidylate synthase map to the short arm of chromosome 18.
G A Silverman, W L Kuo, P Taillon-Miller, J W Gray.
Genomics 1993 Feb; 15(2):442.
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QM, a putative tumor suppressor, regulates proto-oncogene c-yes.
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