TEC polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of TEC polyclonal antibody (Cat # PAB3439) in mouse liver tissue lysate. TEC (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with TEC polyclonal antibody (Cat # PAB3439) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TEC.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to internal region of human TEC.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein G purification
Recommend Usage
Immunofluorescence (1:10-50)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-100)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of TEC polyclonal antibody (Cat # PAB3439) in mouse liver tissue lysate. TEC (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with TEC polyclonal antibody (Cat # PAB3439) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma.Immunofluorescence
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Gene Info — TEC
Entrez GeneID
7006Protein Accession#
TEC_HUMANGene Name
TEC
Gene Alias
MGC126760, MGC126762, PSCTK4
Gene Description
tec protein tyrosine kinase
Omim ID
600583Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome. [provided by RefSeq
Other Designations
OTTHUMP00000158787
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Interactome
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Pathway
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Disease
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Publication Reference
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Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases.
Nore BF, Mattsson PT, Antonsson P, Backesjo CM, Westlund A, Lennartsson J, Hansson H, Low P, Ronnstrand L, Smith CI.
Biochimica et Biophysica Acta 2003 Feb; 1645(2):123.
Application：IP, Human, Ramos cells.
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The AF2 domain of the orphan nuclear receptor TEC is essential for the transcriptional activity of the oncogenic fusion protein EWS/TEC.
Maltais A, Filion C, Labelle Y.
Cancer Letters 2002 Sep; 183(1):87.
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Chemotactic factor-induced recruitment and activation of Tec family kinases in human neutrophils. Implication of phosphatidynositol 3-kinases.
Lachance G, Levasseur S, Naccache PH.
The Journal of Biological Chemistry 2002 Apr; 277(24):21537.
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Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases.
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