DOK5 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of DOK5 polyclonal antibody (Cat # PAB3409) in mouse liver tissue lysate. DOK5 (arrow) was detected using the purified polyclonal antibody
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with DOK5 polyclonal antibody (Cat # PAB3409) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of DOK5.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to amino acids 276-306 of human DOK5.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Ammonium sulfate precipitation
Recommend Usage
ELISA
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-100)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of DOK5 polyclonal antibody (Cat # PAB3409) in mouse liver tissue lysate. DOK5 (arrow) was detected using the purified polyclonal antibodyImmunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with DOK5 polyclonal antibody (Cat # PAB3409) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma.Enzyme-linked Immunoabsorbent Assay
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Gene Info — DOK5
Entrez GeneID
55816Protein Accession#
Q9P104Gene Name
DOK5
Gene Alias
C20orf180, MGC16926
Gene Description
docking protein 5
Omim ID
608334Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. In contrast to other DOK family proteins, this protein does not interact with RASGAP. [provided by RefSeq
Other Designations
OTTHUMP00000031322|downstream of tyrosine kinase 5
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Interactome
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Disease
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Publication Reference
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Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5.
Cai D, Dhe-Paganon S, Melendez PA, Lee J, Shoelson SE.
The Journal of Biological Chemistry 2003 May; 278(28):25323.
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DOK4 and DOK5: new Dok-related genes expressed in human T cells.
Favre C, Gerard A, Clauzier E, Pontarotti P, Olive D, Nunes JA.
Genes and Immunity 2003 Jan; 4(1):40.
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Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5.
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