CASC3 (phospho Y181) polyclonal antibody
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More Files
- More Functions
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human breast carcinomareacted with CASC3 (phospho Y181) polyclonal antibody (Cat # PAB3061), which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of CASC3.
Immunogen
Synthetic phosphopeptide (conjugated with KLH) corresponding to amino acids 166-196 residues surrounding Y181 of human CASC3.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:10-50)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human breast carcinomareacted with CASC3 (phospho Y181) polyclonal antibody (Cat # PAB3061), which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. -
Gene Info — CASC3
Entrez GeneID
22794Protein Accession#
Q8K3W3;NP_619601Gene Name
CASC3
Gene Alias
BTZ, MLN51
Gene Description
cancer susceptibility candidate 3
Omim ID
606504Gene Ontology
HyperlinkGene Summary
The product of this gene is a core component of the exon junction complex (EJC), a protein complex that is deposited on spliced mRNAs at exon-exon junctions and functions in nonsense-mediated mRNA decay (NMD). The encoded protein binds RNA and interacts with two other EJC core components. It is predominantly located in the cytoplasm, but shuttles into the nucleus where it localizes to nuclear speckles. [provided by RefSeq
Other Designations
OTTHUMP00000164448|barentsz|metastatic lymph node 51
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Interactome
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Publication Reference
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Barentsz, a new component of the Staufen-containing ribonucleoprotein particles in mammalian cells, interacts with Staufen in an RNA-dependent manner.
Macchi P, Kroening S, Palacios IM, Baldassa S, Grunewald B, Ambrosino C, Goetze B, Lupas A, St Johnston D, Kiebler M.
The Journal of Neuroscience 2003 Jul; 23(13):5778.
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Metastatic Lymph Node 51, a novel nucleo-cytoplasmic protein overexpressed in breast cancer.
Degot S, Regnier CH, Wendling C, Chenard MP, Rio MC, Tomasetto C.
Oncogene 2002 Jun; 21(28):4422.
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Barentsz, a new component of the Staufen-containing ribonucleoprotein particles in mammalian cells, interacts with Staufen in an RNA-dependent manner.
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