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Western Blot (Cell lysate)

Western blot analysis of EPHA1 polyclonal antibody (Cat # PAB3002) in HeLa cell lysate. EPHA1 (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma.

Entrez GeneID

2041

Protein Accession#

P21709

Gene Name

EPHA1

Gene Alias

EPH, EPHT, EPHT1, MGC163163

Gene Description

EPH receptor A1

Omim ID

179610

Gene Ontology

Hyperlink

Gene Summary

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis. [provided by RefSeq

Other Designations

eph tyrosine kinase 1|ephrin receptor EphA1|ephrin type-A receptor 1|erythropoietin-producing hepatoma amplified sequence|oncogene EPH|soluble EPHA1 variant 1|soluble EPHA1 variant 2|tyrosine-protein kinase receptor EPH