CLOCK polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CLOCK.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to internal region of human CLOCK.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Ammonium sulfate precipitation
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:10-50)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of NCI-H460 cell lysate (35 ug/lane) with CLOCK polyclonal antibody (Cat # PAB2981).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human prostate carcinoma tissue reacted with CLOCK polyclonal antibody (Cat # PAB2981) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. -
Gene Info — CLOCK
Entrez GeneID
9575Protein Accession#
NP_004889;O15516Gene Name
CLOCK
Gene Alias
KAT13D, KIAA0334, bHLHe8
Gene Description
clock homolog (mouse)
Omim ID
601851Gene Ontology
HyperlinkGene Summary
This gene encodes a protein that belongs to the basic helix-loop-helix (bHLH) family of transcription factors. Polymorphisms within the encoded protein have been associated with circadian rhythm sleep disorders. A similar protein in mice is a circadian regulator that acts as a transcription factor and forms a heterodimer with aryl hydrocarbon receptor nuclear translocator-like to activate transcription of mouse period 1. [provided by RefSeq
Other Designations
OTTHUMP00000128334|circadian locomoter output cycles kaput protein|clock
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Interactome
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Pathway
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Disease
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Publication Reference
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Genetic variants of Clock transcription factor are associated with individual susceptibility to obesity.
Sookoian S, Gemma C, Gianotti TF, Burgueno A, Castano G, Pirola CJ.
The American Journal of Clinical Nutrition 2008 Jun; 87(6):1606.
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Shift work, hCLOCK T3111C polymorphism, and endometriosis risk.
Marino JL, Holt VL, Chen C, Davis S.
Epidemiology 2008 May; 19(3):477.
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DEC1 modulates the circadian phase of clock gene expression.
Nakashima A, Kawamoto T, Honda KK, Ueshima T, Noshiro M, Iwata T, Fujimoto K, Kubo H, Honma S, Yorioka N, Kohno N, Kato Y.
Molecular and Cellular Biology 2008 Jun; 28(12):4080.
Application:ChIP, Human, Human fibroblast-like cells.
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Genetic variants of Clock transcription factor are associated with individual susceptibility to obesity.
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