CDC2 polyclonal antibody
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More Files
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Western Blot (Cell lysate)
Western blot analysis of CDC2 polyclonal antibody (Cat # PAB2910) in A-375 cell lysate. CDC2 (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CDC2.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human CDC2.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of CDC2 polyclonal antibody (Cat # PAB2910) in A-375 cell lysate. CDC2 (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence. -
Gene Info — CDC2
Entrez GeneID
983Protein Accession#
NP_001777;P06493Gene Name
CDC2
Gene Alias
CDC28A, CDK1, DKFZp686L20222, MGC111195
Gene Description
cell division cycle 2, G1 to S and G2 to M
Omim ID
116940Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000019660|cell cycle controller CDC2|cell division control protein 2 homolog|cell division cycle 2 protein|cyclin-dependent kinase 1|p34 protein kinase
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Interactome
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Pathway
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Disease
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Publication Reference
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Differential contribution of inhibitory phosphorylation of CDC2 and CDK2 for unperturbed cell cycle control and DNA integrity checkpoints.
Chow JP, Siu WY, Ho HT, Ma KH, Ho CC, Poon RY.
The Journal of Biological Chemistry 2003 Oct; 278(42):40815.
Application：WB-Ce, Human, Mouse, HtTA1, HeLa, 3T3 cells.
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p34cdc2 expression is an independent indicator for lymph node metastasis in colorectal carcinoma.
Nozoe T, Honda M, Inutsuka S, Korenaga D.
Journal of Cancer Research and Clinical Oncology 2003 Sep; 129(9):498.
Application：IHC-P, Human, Human colorectal carcinoma.
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Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase.
Margottin-Goguet F, Hsu JY, Loktev A, Hsieh HM, Reimann JD, Jackson PK.
Developmental Cell 2003 Jun; 4(6):813.
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Differential contribution of inhibitory phosphorylation of CDC2 and CDK2 for unperturbed cell cycle control and DNA integrity checkpoints.
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