TGIF1 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of TGIF1 polyclonal antibody (Cat # PAB2851) in Y-79 cell line lysates (35 ug/lane). TGIF1 (arrow) was detected using the purified polyclonal antibody.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TGIF1.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to internal region of human TGIF1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Ammonium sulfate precipitation
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of TGIF1 polyclonal antibody (Cat # PAB2851) in Y-79 cell line lysates (35 ug/lane). TGIF1 (arrow) was detected using the purified polyclonal antibody. -
Gene Info — TGIF1
Entrez GeneID
7050Protein Accession#
NP_003235;Q15583Gene Name
TGIF1
Gene Alias
HPE4, MGC39747, MGC5066, TGIF
Gene Description
TGFB-induced factor homeobox 1
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and eight variants, encoding four distinct isoforms, are described. [provided by RefSeq
Other Designations
5'-TG-3' interacting factor|TALE homeobox TG-interacting factor|TG-interacting factor|homeobox protein TGIF|transforming growth factor-beta-induced factor
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Interactome
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Disease
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Publication Reference
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Assessment of TGIF as a candidate gene for myopia.
Pertile KK, Schache M, Islam FM, Chen CY, Dirani M, Mitchell P, Baird PN.
Investigative Ophthalmology & Visual Science 2008 Jan; 49(1):49.
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TGFB-induced factor (TGIF): a candidate gene for psychosis on chromosome 18p.
Chavarria-Siles I, Walss-Bass C, Quezada P, Dassori A, Contreras S, Medina R, Ramirez M, Armas R, Salazar R, Leach RJ, Raventos H, Escamilla MA.
Molecular Psychiatry 2007 Nov; 12(11):1033.
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A mechanism for mutational inactivation of the homeodomain protein TGIF in holoprosencephaly.
Ferrand N, Demange C, Prunier C, Seo SR, Atfi A.
FASEB Journal 2006 Dec; 21(2):488.
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Assessment of TGIF as a candidate gene for myopia.
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