CRK polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of CRK polyclonal antibody (Cat # PAB27043) in extracts from HeLa cells at 1:500 dilution.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of CRK polyclonal antibody (Cat # PAB27043) in paraffin-embedded human lung carcinoma tissue.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CRK.
Immunogen
A synthetic peptide corresponding to human CRK.
Host
Rabbit
Theoretical MW (kDa)
38
Reactivity
Human, Mouse, Rat
Specificity
CRK polyclonal antibody detects endogenous levels of CRK protein.
Form
Liquid
Purification
Antigen affinity purification
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:200)
Immunofluorescence (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of CRK polyclonal antibody (Cat # PAB27043) in extracts from HeLa cells at 1:500 dilution.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of CRK polyclonal antibody (Cat # PAB27043) in paraffin-embedded human lung carcinoma tissue.Immunofluorescence
Enzyme-linked Immunoabsorbent Assay
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Gene Info — CRK
Entrez GeneID
1398Protein Accession#
P46108Gene Name
CRK
Gene Alias
CRKII
Gene Description
v-crk sarcoma virus CT10 oncogene homolog (avian)
Omim ID
164762Gene Ontology
HyperlinkGene Summary
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq
Other Designations
avian sarcoma virus CT10 (v-crk) oncogene homolog|v-crk avian sarcoma virus CT10 oncogene homolog|v-crk sarcoma virus CT10 oncogene homolog
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Interactome
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Pathway
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