Products

Western Blot (Tissue lysate)

Western blot analysis of ACVR2A polyclonal antibody (Cat # PAB2643) in mouse liver, brain and kidney tissue lysates (35 ug/lane). ACVR2A (arrow) was detected using the purified polyclonal antibody.

Western Blot (Transfected lysate)

Western blot analysis of ACVR2A (arrow) using ACVR2A polyclonal antibody (Cat # PAB2643). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the ACVR2A gene (Lane 2) (Origene Technologies).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with ACVR2A polyclonal antibody (Cat # PAB2643) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma.

Entrez GeneID

92

Protein Accession#

NP_001607;P27037

Gene Name

ACVR2A

Gene Alias

ACTRII, ACVR2

Gene Description

activin A receptor, type IIA

Omim ID

102581

Gene Ontology

Hyperlink

Gene Summary

This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. [provided by RefSeq

Other Designations

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