AKR1B1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of AKR1B1.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human AKR1B1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Ammonium sulfate precipitation
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:10-50)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of AKR1B1 polyclonal antibody (Cat # PAB2581) in A-375 cell line lysates (35 ug/lane).AKR1B1 (arrow) was detected using the purified polyclonal antibody.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with AKR1B1 polyclonal antibody (Cat # PAB2581) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. -
Gene Info — AKR1B1
Entrez GeneID
231Protein Accession#
NP_001619;P15121Gene Name
AKR1B1
Gene Alias
ADR, ALDR1, ALR2, AR, MGC1804
Gene Description
aldo-keto reductase family 1, member B1 (aldose reductase)
Omim ID
103880Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq
Other Designations
Lii5-2 CTCL tumor antigen|aldehyde reductase 1|aldo-keto reductase family 1, member B1|aldose reductase|low Km aldose reductase
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Interactome
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Pathway
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Disease
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Publication Reference
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Identification of multiple and distinct defects in prostaglandin biosynthetic pathways in eutopic and ectopic endometrium of women with endometriosis.
Rakhila H, Carli C, Daris M, Lemyre M, Leboeuf M, Akoum A.
Fertility and Sterility 2013 Dec; 100(6):1650.
Application:IHC-P, Human, Endometrium.
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Upregulation of aldose reductase during foam cell formation as possible link among diabetes, hyperlipidemia, and atherosclerosis.
Gleissner CA, Sanders JM, Nadler J, Ley K.
Arteriosclerosis, Thrombosis, and Vascular Biology 2008 May; 28(6):1137.
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Merging the binding sites of aldose and aldehyde reductase for detection of inhibitor selectivity-determining features.
Steuber H, Heine A, Podjarny A, Klebe G.
Journal of Molecular Biology 2008 Apr; 379(5):991.
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Cloning and prokaryotic expression of a biologically active human placental aldose reductase.
Grundmann U, Bohn H, Obermeier R, Amann E.
DNA and Cell Biology 1990 Apr; 9(3):149.
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Identification of multiple and distinct defects in prostaglandin biosynthetic pathways in eutopic and ectopic endometrium of women with endometriosis.
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