Products

Western Blot (Cell lysate)

Western blot analysis of HepG2 whole cell lysate with ACSL4 polyclonal antibody (Cat # PAB2504) followed by HRP conjugated goat anti-rabbit IgG (H+L) as second antibody.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with the ACSL4 polyclonal antibody (Cat # PAB2504) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma.

Entrez GeneID

2182

Protein Accession#

ACSL4_HUMAN

Gene Name

ACSL4

Gene Alias

ACS4, FACL4, LACS4, MRX63, MRX68

Gene Description

acyl-CoA synthetase long-chain family member 4

Omim ID

300157 300387

Gene Ontology

Hyperlink

Gene Summary

The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the mental retardation or Alport syndrome. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq

Other Designations

OTTHUMP00000023846|acyl-CoA synthetase 4|fatty-acid-Coenzyme A ligase, long-chain 4|lignoceroyl-CoA synthase|long-chain fatty-acid-Coenzyme A ligase 4