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Western Blot

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunoprecipitation

Entrez GeneID

Gene Name

ATF4

Gene Alias

CREB-2, CREB2, TAXREB67, TXREB

Gene Description

activating transcription factor 4 (tax-responsive enhancer element B67)

Omim ID

Gene Ontology

Gene Summary

This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromsome at q28 in a region containing a large inverted duplication. [provided by RefSeq

Other Designations

activating transcription factor 4|cAMP response element-binding protein 2