BCL2A1 polyclonal antibody
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More Files
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Western Blot (Tissue lysate)
Western blot analysis of BCL2A1 polyclonal antibody (Cat # PAB2438) in human placenta tissue lysate. BCL2A1 (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the BCL2A1 polyclonal antibody (Cat # PAB2438) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of BCL2A1.
Immunogen
A synthetic peptide corresponding to N-terminus of human BCL2A1.
Host
Rabbit
Reactivity
Human
Specificity
BH3 Domain Specific
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of BCL2A1 polyclonal antibody (Cat # PAB2438) in human placenta tissue lysate. BCL2A1 (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the BCL2A1 polyclonal antibody (Cat # PAB2438) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma. -
Gene Info — BCL2A1
Entrez GeneID
597Protein Accession#
NP_004040;Q16548Gene Name
BCL2A1
Gene Alias
ACC-1, ACC-2, BCL2L5, BFL1, GRS, HBPA1
Gene Description
BCL2-related protein A1
Omim ID
601056Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
hematopoietic BCL2-related protein A1
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Interactome
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Pathway
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Disease
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Publication Reference
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Gene expression changes and signaling events associated with the direct antimelanoma effect of IFN-gamma.
Gollob JA, Sciambi CJ, Huang Z, Dressman HK.
Cancer Research 2005 Oct; 65(19):8869.
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Gene expression changes and signaling events associated with the direct antimelanoma effect of IFN-gamma.
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