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Last updated: 2014/7/28
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FGFR1 polyclonal antibody

  • Catalog # : PAB2086
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of FGFR1.
  • Immunogen:
  • A synthetic peptide (conjugated with KLH) corresponding to residues surrounding Y766 of human FGFR1.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Purification:
  • Protein A purification
  • Recommend Usage:
  • ELISA (1:1000)
    Western Blot (1:50-100)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Transfected lysate)
  • Western Blot (Transfected lysate)
  • Western blot analysis of FGFR1 (arrow) using FGFR1 polyclonal antibody (Cat # PAB2086). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the FGFR1 gene (Lane 2) (Origene Technologies).
  • ELISA
  • Application Image
  • Western Blot (Transfected lysate)
  • Western Blot (Transfected lysate)
  • enlarge
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 2260
  • Protein Accession#:
  • NP_000595;P11362
  • Gene Name:
  • FGFR1
  • Gene Alias:
  • BFGFR,CD331,CEK,FGFBR,FLG,FLJ99988,FLT2,HBGFR,KAL2,N-SAM
  • Gene Description:
  • fibroblast growth factor receptor 1
  • Gene Summary:
  • The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq
  • Other Designations:
  • FMS-like tyrosine kinase 2,OTTHUMP00000190874,OTTHUMP00000190878,OTTHUMP00000190879,OTTHUMP00000190881,basic fibroblast growth factor receptor 1,fms-related tyrosine kinase 2,fms-related tyrosine kinase-2,heparin-binding growth factor receptor,hydroxyaryl
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