FGFR1 polyclonal antibody
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Specifications
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of FGFR1.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to residues surrounding Y766 of human FGFR1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western blot analysis of FGFR1 (arrow) using FGFR1 polyclonal antibody (Cat # PAB2086). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the FGFR1 gene (Lane 2) (Origene Technologies). -
Gene Info — FGFR1
Entrez GeneID
2260Protein Accession#
NP_000595;P11362Gene Name
FGFR1
Gene Alias
BFGFR, CD331, CEK, FGFBR, FLG, FLJ99988, FLT2, HBGFR, KAL2, N-SAM
Gene Description
fibroblast growth factor receptor 1
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq
Other Designations
FMS-like tyrosine kinase 2|OTTHUMP00000190874|OTTHUMP00000190878|OTTHUMP00000190879|OTTHUMP00000190881|basic fibroblast growth factor receptor 1|fms-related tyrosine kinase 2|fms-related tyrosine kinase-2|heparin-binding growth factor receptor|hydroxyaryl
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Interactomes
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Pathways
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Diseases
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Publication Reference
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Differential tyrosine phosphorylation of fibroblast growth factor (FGF) receptor-1 and receptor proximal signal transduction in response to FGF-2 and heparin.
Lundin L, Ronnstrand L, Cross M, Hellberg C, Lindahl U, Claesson-Welsh L.
Experimental Cell Research 2003 Jul; 287(1):190.
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Expression patterns of epidermal growth factor receptor and fibroblast growth factor receptor 1 mRNA in fetal human brain.
Fu L, Abu-Khalil A, Morrison RS, Geschwind DH, Kornblum HI.
The Journal of Comparative Neurology 2003 Jul; 462(2):265.
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Alternatively spliced FGFR-1 isoform signaling differentially modulates endothelial cell responses to peroxynitrite.
Jiao J, Greendorfer JS, Zhang P, Zinn KR, Diglio CA, Thompson JA.
Archives of Biochemistry and Biophysics 2003 Feb; 410(2):187.
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Differential tyrosine phosphorylation of fibroblast growth factor (FGF) receptor-1 and receptor proximal signal transduction in response to FGF-2 and heparin.
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