PODXL polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human kidney with PODXL polyclonal antibody (Cat # PAB20111) shows strong cytoplasmic positivity in cells in glomeruli at 1:200-1:500 dilution.
Immunofluorescence
Immunofluorescent staining of human cell line U-251 MG with PODXL polyclonal antibody (Cat # PAB20111) at 1-4 ug/mL dilution shows positivity in nucleoli, plasma membrane, vesicles, centrosome.
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant PODXL.
Immunogen
Recombinant protein corresponding to amino acids of human PODXL.
Sequence
LPETMSSSPTAASTTHRYPKTPSPTVAHESNWAKCEDLETQTQSEKQLVLNLTGNTLCAGGASDEKLISLICRAVKATFNPAQDKCGIRLASVPGSQTVVVKEITIHTKLPAKDVYERLKDKWDELKEAGVSDMKLGD
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:200-1:500)
Western Blot (1:250-1:500)
Immunofluorescence (1-4 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human kidney with PODXL polyclonal antibody (Cat # PAB20111) shows strong cytoplasmic positivity in cells in glomeruli at 1:200-1:500 dilution.Immunofluorescence
Immunofluorescent staining of human cell line U-251 MG with PODXL polyclonal antibody (Cat # PAB20111) at 1-4 ug/mL dilution shows positivity in nucleoli, plasma membrane, vesicles, centrosome. -
Gene Info — PODXL
Entrez GeneID
5420Protein Accession#
O00592Gene Name
PODXL
Gene Alias
Gp200, MGC138240, PC, PCLP
Gene Description
podocalyxin-like
Omim ID
602632Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the sialomucin protein family. The encoded protein was originally identified as an important component of glomerular podocytes. Podocytes are highly differentiated epithelial cells with interdigitating foot processes covering the outer aspect of the glomerular basement membrane. Other biological activities of the encoded protein include: binding in a membrane protein complex with Na+/H+ exchanger regulatory factor to intracellular cytoskeletal elements, playing a role in hematopoetic cell differentiation, and being expressed in vascular endothelium cells and binding to L-selectin. [provided by RefSeq
Other Designations
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Interactome
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Disease
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Publication Reference
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Measurement of serum PODXL concentration for detection of pancreatic cancer.
Taniuchi K, Tsuboi M, Sakaguchi M, Saibara T.
OncoTargets and Therapy 2018 Mar; 11:1433.
Application：IF, WB, Human, HPNE, PANC-1, S2-013 cells.
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Measurement of serum PODXL concentration for detection of pancreatic cancer.
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