SIM2 polyclonal antibody
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More Files
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Western Blot (Tissue lysate)
SIM2 polyclonal antibody (Cat # PAB18984, 0.5 ug/mL) staining of fetal mouse kidney lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of SIM2.
Immunogen
A synthetic peptide corresponding to amino acids at internal region of human SIM2.
Sequence
C-SDLLYTPSYS
Host
Goat
Theoretical MW (kDa)
80
Reactivity
Human, Mouse
Specificity
This antibody is expected to recognize all reported isoforms (NP_005060.1; NP_033664.2).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:1000)
Western Blot (0.5-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 0.5 mg/mL in Tris saline, pH7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
SIM2 polyclonal antibody (Cat # PAB18984, 0.5 ug/mL) staining of fetal mouse kidney lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — SIM2
Entrez GeneID
6493Protein Accession#
NP_005060.1;NP_033664.2Gene Name
SIM2
Gene Alias
MGC119447, SIM, bHLHe15
Gene Description
single-minded homolog 2 (Drosophila)
Omim ID
600892Gene Ontology
HyperlinkGene Summary
SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. The Drosophila sim gene encodes a transcription factor that is a master regulator of fruit fly neurogenesis. SIM2 maps within the so-called Down syndrome chromosomal region. Based on the mapping position, its potential function as transcriptional repressor and similarity to Drosophila sim, it is proposed that SIM2 may contribute to some specific Down syndrome phenotypes [provided by RefSeq
Other Designations
single-minded homolog 2|single-minded homolog 2, short isoform|transcription factor SIM2
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Interactome
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Disease
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