MMP14 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of MCF-7 cell lysate with MMP14 polyclonal antibody (Cat # PAB18771) at 1 : 200 dilution.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of formalin-fixed paraffin-embedded human breast carcinoma tissue showing cytoplasmic staining with MMP14 polyclonal antibody (Cat # PAB18771) at 1 : 100 dilution.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of MMP14.
Immunogen
A synthetic peptide corresponding to 14 amino acids at internal region of human MMP14.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Purification
Peptide affinity purification
Recommend Usage
ELISA (1:10000-1:10000)
Western Blot (1:200-1:500)
Immunohistochemistry (1:50-1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In buffer containing 0.02% sodium azide
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of MCF-7 cell lysate with MMP14 polyclonal antibody (Cat # PAB18771) at 1 : 200 dilution.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of formalin-fixed paraffin-embedded human breast carcinoma tissue showing cytoplasmic staining with MMP14 polyclonal antibody (Cat # PAB18771) at 1 : 100 dilution.Enzyme-linked Immunoabsorbent Assay
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Gene Info — MMP14
Entrez GeneID
4323Gene Name
MMP14
Gene Alias
MMP-X1, MT1-MMP, MTMMP1
Gene Description
matrix metallopeptidase 14 (membrane-inserted)
Omim ID
600754Gene Ontology
HyperlinkGene Summary
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq
Other Designations
matrix metalloproteinase 14|matrix metalloproteinase 14 (membrane-inserted)|membrane type 1 metalloprotease|membrane-type matrix metalloproteinase 1|membrane-type-1 matrix metalloproteinase
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Interactome
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Pathway
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Disease
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Publication Reference
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Analysis of Membrane Type-1 Matrix Metalloproteinase (MT1-MMP, MMP14) in Eutopic and Ectopic Endometrium and in Serum and Endocervical Mucus of Endometriosis.
Jane B Maoga, Muhammad A Riaz, Agnes N Mwaura, Ezekiel Mecha, Charles O A Omwandho, Georgios Scheiner-Bobis, Ivo Meinhold-Heerlein, Lutz Konrad.
Biomedicines 2023 Oct; 11(10):2730.
Application：IHC, Human, Bouin-fixed endometrium tissue.
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Analysis of Membrane Type-1 Matrix Metalloproteinase (MT1-MMP, MMP14) in Eutopic and Ectopic Endometrium and in Serum and Endocervical Mucus of Endometriosis.
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