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Last updated: 2014/10/20
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ABCC8 polyclonal antibody

  • Catalog # : PAB18689
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  • Specification
  • Product Description:
  • Goat polyclonal antibody raised against synthetic peptide of ABCC8.
  • Immunogen:
  • A synthetic peptide corresponding to amino acids at C-terminus of human ABCC8.
  • Sequence:
  • C-EFDKPEKLLSRKD
  • Host:
  • Goat
  • Theoretical MW (kDa):
  • 170
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Purification:
  • Antigen affinity purification
  • Concentration:
  • 0.5 mg/mL
  • Recommend Usage:
  • ELISA (1:8000)
    Western blot (0.5-1.5 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In Tris saline, pH 7.3 (0.02% sodium azide, 0.5% BSA)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • ABCC8 polyclonal antibody (Cat # PAB18689) (0.5 ug/mL) staining of human cerebellum lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
  • ELISA
  • Application Image
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • enlarge
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 6833
  • Gene Name:
  • ABCC8
  • Gene Alias:
  • ABC36,HHF1,HI,HRINS,MRP8,PHHI,SUR,SUR1,TNDM2
  • Gene Description:
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 8
  • Gene Summary:
  • The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternative splicing of this gene has been observed; however, the transcript variants have not been fully described. [provided by RefSeq
  • Other Designations:
  • ATP-binding cassette, sub-family C, member 8,sulfonylurea receptor (hyperinsulinemia)
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