GAB1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of GAB1.
Immunogen
A synthetic peptide corresponding to residues surrounding Y659 of human GAB1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody is specific to GAB1.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
Immunofluorescence (1:500-1:1000)
ELISA (1:10000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from NIH/3T3 cells, using GAB1 polyclonal antibody (Cat # PAB18276).
Peptide "+" means "peptide blocking".Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using GAB1 polyclonal antibody (Cat # PAB18276).
Peptide "+" means "peptide blocking".Immunofluorescence
Immunofluorescence analysis of HepG2 cells, using GAB1 polyclonal antibody (Cat # PAB18276).
Peptide "+" means "peptide blocking".Enzyme-linked Immunoabsorbent Assay
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Gene Info — GAB1
Entrez GeneID
2549Protein Accession#
Q13480Gene Name
GAB1
Gene Alias
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Gene Description
GRB2-associated binding protein 1
Omim ID
604439Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
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Interactome
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Pathway
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Disease
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Publication Reference
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The scaffolding adapter Gab1 mediates vascular endothelial growth factor signaling and is required for endothelial cell migration and capillary formation.
Laramee M, Chabot C, Cloutier M, Stenne R, Holgado-Madruga M, Wong AJ, Royal I.
The Journal of Biological Chemistry 2007 Mar; 282(11):7758.
Application:IP, WB, Bovine, Bovine aortic endothelial cell.
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Gab1 contributes to cytoskeletal reorganization and chemotaxis in response to platelet-derived growth factor.
Kallin A, Demoulin JB, Nishida K, Hirano T, Ronnstrand L, Heldin CH.
The Journal of Biological Chemistry 2004 Apr; 279(17):17897.
Application:IP-WB, Human, PAE cells.
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Distinct recruitment and function of Gab1 and Gab2 in Met receptor-mediated epithelial morphogenesis.
Lock LS, Maroun CR, Naujokas MA, Park M.
Molecular Biology of the Cell 2002 Jun; 13(6):2132.
Application:IP-WB, Dog, MDCK cells.
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The scaffolding adapter Gab1 mediates vascular endothelial growth factor signaling and is required for endothelial cell migration and capillary formation.
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