Western blot analysis of extracts from NIH/3T3 cells treated with PBS (60 min), using NTRK2 polyclonal antibody (Cat # PAB18110). Peptide "+" means "peptide blocking".
Immunohistochemical analysis of paraffin-embedded human brain tissue using NTRK2 polyclonal antibody (Cat # PAB18110). Peptide "+" means "peptide blocking".
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations:
BDNF/NT-3 growth factors receptor,OTTHUMP00000021573,OTTHUMP00000021574,OTTHUMP00000021575,OTTHUMP00000021576,OTTHUMP00000021577,tyrosine kinase receptor B