CREB1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CREB1.
Immunogen
A synthetic peptide corresponding to human CREB1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody is specific to CREB1.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
Immunofluorescence (1:500-1:1000)
ELISA (1:40000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from HeLa cells treated with PMA (125 ng/mL, 30 min), using CREB1 polyclonal antibody (Cat # PAB18091).
Peptide "+" means "peptide blocking".Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using CREB1 polyclonal antibody (Cat # PAB18091).
Peptide "+" means "peptide blocking".Immunofluorescence
Immunofluorescence analysis of HeLa cells, treated with PMA (125 ng/mL, 30 mins), using CREB1 polyclonal antibody (Cat # PAB18091).
Peptide "+" means "peptide blocking".Enzyme-linked Immunoabsorbent Assay
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Gene Info — CREB1
Entrez GeneID
1385Protein Accession#
P16220Gene Name
CREB1
Gene Alias
CREB, MGC9284
Gene Description
cAMP responsive element binding protein 1
Omim ID
123810Gene Ontology
HyperlinkGene Summary
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq
Other Designations
active transcription factor CREB|cAMP-response element-binding protein-1|transactivator protein
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Interactome
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Pathway
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Disease
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Publication Reference
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Activation of D1-like dopamine receptors is involved in the impairment of spatial memory in the offspring of morphine-abstinent rats.
Ghorbangol Ashabi, Maral Matloob, Nazanin Monfared Neirizi, Mojtaba Behrouzi, Mohammad Safarzadeh, Aryaan Rajabpoor Dehdashti, Mitra-Sadat Sadat-Shirazi, Mohammad-Reza Zarrindast.
Neuroscience Research 2020 Sep; 158:37.
Application:WB, Rat, Rat offspring.
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Activity-dependent neuroprotection and cAMP response element-binding protein (CREB): kinase coupling, stimulus intensity, and temporal regulation of CREB phosphorylation at serine 133.
Lee B, Butcher GQ, Hoyt KR, Impey S, Obrietan K.
Journal of Neuroscience 2005 Feb; 25(5):1137.
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Cyclic adenosine 3',5'-monophosphate (cAMP) enhances cAMP-responsive element binding (CREB) protein phosphorylation and phospho-CREB interaction with the mouse steroidogenic acute regulatory protein gene promoter.
Clem BF, Hudson EA, Clark BJ.
Endocrinology 2005 Mar; 146(3):1348.
Application:ChIP, WB, Mouse, MA-10 cells.
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Activation of D1-like dopamine receptors is involved in the impairment of spatial memory in the offspring of morphine-abstinent rats.
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