APC polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of APC.
Immunogen
A synthetic peptide corresponding to human APC.
Host
Rabbit
Reactivity
Human
Specificity
This antibody is specific to APC.
Form
Liquid
Recommend Usage
Immunohistochemistry (1:50~1:100)
ELISA (1:40000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry analysis of paraffin-embedded human brain tissue using APC polyclonal antibody (Cat # PAB18087).
Peptide "+" means "with peptide blocking".Immunohistochemistry
Enzyme-linked Immunoabsorbent Assay
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Gene Info — APC
Entrez GeneID
324Protein Accession#
P25054Gene Name
APC
Gene Alias
BTPS2, DP2, DP2.5, DP3, GS
Gene Description
adenomatous polyposis coli
Gene Ontology
HyperlinkGene Summary
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq
Other Designations
adenomatosis polyposis coli tumor suppressor
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Interactome
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Pathway
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Disease
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Publication Reference
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Truncated APC regulates the transcriptional activity of beta-catenin in a cell cycle dependent manner.
Schneikert J, Grohmann A, Behrens J.
Human Molecular Genetics 2007 Jan; 16(2):199.
Application:WB-Tr, Human, SW480 cells.
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Class II MHC/peptide complexes are released from APC and are acquired by T cell responders during specific antigen recognition.
Patel DM, Arnold PY, White GA, Nardella JP, Mannie MD.
Journal of Immunology 1999 Nov; 163(10):5201.
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Colossal crypts bordering colon adenomas in Apc(Min) mice express full-length Apc.
Bjerknes M, Cheng H.
The American Journal of Pathology 1999 Jun; 154(6):1831.
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AOM-induced mouse colon tumors do not express full-length APC protein.
T Maltzman, J Whittington, L Driggers, J Stephens, D Ahnen.
Carcinogenesis 1997 Dec; 18(12):2435.
Application:IHC-Fr, Mouse, Mouse intestine.
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Truncated APC regulates the transcriptional activity of beta-catenin in a cell cycle dependent manner.
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