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Last updated: 2014/10/27
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RAF1 (phospho S259) polyclonal antibody

  • Catalog # : PAB17919
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic phosphopeptide of RAF1.
  • Immunogen:
  • Synthetic phosphopeptide corresponding to residues surrounding S259 of human RAF1.
  • Host:
  • Rabbit
  • Reactivity:
  • Human, Mouse, Rat
  • Specificity:
  • This antibody detects ~74 KDa c-Raf when phosphorylated at Ser259.
  • Form:
  • Liquid
  • Recommend Usage:
  • Western Blot (0.5-4 ug/mL)
    Immunohistochemistry (20-40 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS pH 7.2 (50% glycerol, 1% BSA, 0.02% thimerosal)
  • Storage Instruction:
  • Store at -20°C. For long term storage store at -80°.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains thimerosal: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot
  • Immunohistochemistry
  • Application Image
  • Western Blot
  • Immunohistochemistry
  • Gene Information
  • Entrez GeneID:
  • 5894
  • Gene Name:
  • RAF1
  • Gene Alias:
  • CRAF,NS5,Raf-1,c-Raf
  • Gene Description:
  • v-raf-1 murine leukemia viral oncogene homolog 1
  • Gene Summary:
  • This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq
  • Other Designations:
  • Oncogene RAF1,raf proto-oncogene serine/threonine protein kinase
  • Interactome
  • Interactome
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