COL6A3 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of COL6A3.
Immunogen
A synthetic peptide corresponding to amino acids 2261-2310 of human COL6A3.
Host
Rabbit
Theoretical MW (kDa)
343
Reactivity
Human, Mouse
Specificity
This antibody detects endogenous levels of total COL6A3 protein.
Form
Liquid
Purification
The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.
Recommend Usage
ELISA (1:40000)
Immunofluorescence (1:100-1:500)
Immunohistochemistry (1:50-1:100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (without Mg2+ and Ca2+), 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide).
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using COL6A3 polyclonal antibody (Cat # PAB17517).
Peptide "+" means "with peptide blocking".Immunofluorescence
Immunofluorescence analysis of HeLa cells, using COL6A3 polyclonal antibody (Cat # PAB17517).
Peptide "+" means "with peptide blocking".Enzyme-linked Immunoabsorbent Assay
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Gene Info — COL6A3
Entrez GeneID
1293Protein Accession#
P12111Gene Name
COL6A3
Gene Alias
DKFZp686D23123, DKFZp686K04147, DKFZp686N0262, FLJ34702, FLJ98399
Gene Description
collagen, type VI, alpha 3
Gene Ontology
HyperlinkGene Summary
This gene encodes the alpha-3 chain, one of the three alpha chains of type VI collagen, a beaded filament collagen found in most connective tissues. The alpha-3 chain of type VI collagen is much larger than the alpha-1 and -2 chains. This difference in size is largely due to an increase in the number of subdomains, similar to von Willebrand Factor type A domains, that are found in the amino terminal globular domain of all the alpha chains. These domains have been shown to bind extracellular matrix proteins, an interaction that explains the importance of this collagen in organizing matrix components. Mutations in the type VI collagen genes are associated with Bethlem myopathy, a rare autosomal dominant proximal myopathy with early childhood onset. Mutations in this gene are also a cause of Ullrich congenital muscular dystrophy, also referred to as Ullrich scleroatonic muscular dystrophy, an autosomal recessive congenital myopathy that is more severe than Bethlem myopathy. Multiple transcript variants have been identified, but the full-length nature of only some of these variants has been described. [provided by RefSeq
Other Designations
alpha 3 type VI collagen|collagen VI, alpha-3 polypeptide
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Interactome
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Pathway
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Disease
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Publication Reference
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TAF4 Inactivation Reveals the 3 Dimensional Growth Promoting Activities of Collagen 6A3.
Martianov I, Cler E, Duluc I, Vicaire S, Philipps M, Freund JN, Davidson I.
PLoS One 2014 Feb; 9(2):e87365.
Application:IF, Mouse, MEFs.
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TAF4 Inactivation Reveals the 3 Dimensional Growth Promoting Activities of Collagen 6A3.
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