COL4A6 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of COL4A6.
Immunogen
A synthetic peptide corresponding to amino acids at internal region of human COL4A6.
Sequence
C-PSPEFETETLHNKES
Host
Goat
Theoretical MW (kDa)
164
Specificity
This antibody is expected to recognize both reported isoforms (NP_001838.2; NP_378667.1).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:32000)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Enzyme-linked Immunoabsorbent Assay
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Gene Info — COL4A6
Entrez GeneID
1288Protein Accession#
NP_001838.2;NP_378667.1Gene Name
COL4A6
Gene Alias
MGC88184
Gene Description
collagen, type IV, alpha 6
Gene Ontology
HyperlinkGene Summary
This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene, alpha 5 type IV collagen, so that the gene pair shares a common promoter. Deletions in the alpha 5 gene that extend into the alpha 6 gene result in diffuse leiomyomatosis accompanying the X-linked Alport syndrome caused by the deletion in the alpha 5 gene. Two splice variants have been identified for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000023834|OTTHUMP00000023835|collagen IV, alpha-6 polypeptide|collagen alpha 6 type IV|collagen of basement membrane, alpha-6|dJ889N15.4 (Collagen Alpha 6(IV))|type IV alpha 6 collagen
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Interactome
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Pathway
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Disease
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Publication Reference
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Structure of the human type IV collagen COL4A6 gene, which is mutated in Alport syndrome-associated leiomyomatosis.
Zhang X, Zhou J, Reeders ST, Tryggvason K.
Genomics 1996 May; 33(3):473.
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Structure of the human type IV collagen COL4A6 gene, which is mutated in Alport syndrome-associated leiomyomatosis.
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