GAB1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of GAB1.
Immunogen
A synthetic peptide corresponding to residues surrounding Y659 of human GAB1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody detects endogenous levels of total GAB1 protein.
Form
Liquid
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
ELISA (1:20000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 20 mM PBS, 0.15 M NaCl, pH 7.2 (0.01% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human hepatocellular carcinoma tissue using GAB1 polyclonal antibody (Cat # PAB17007).Enzyme-linked Immunoabsorbent Assay
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Gene Info — GAB1
Entrez GeneID
2549Protein Accession#
Q13480Gene Name
GAB1
Gene Alias
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Gene Description
GRB2-associated binding protein 1
Omim ID
604439Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
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Interactome
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Pathway
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Disease
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Publication Reference
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Activation of Gab1 in pancreatic acinar cells: effects of gastrointestinal growth factors/hormones on stimulation, phosphospecific phosphorylation, translocation and interaction with downstream signaling molecules.
Hoffmann KM, Tapia JA, Jensen RT.
Cellular Signalling 2006 Jul; 18(7):942.
Application:IP, WB, Mouse, Rat, NIH/3T3 cells, Rat panc acini.
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A novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activation.
Montagner A, Yart A, Dance M, Perret B, Salles JP, Raynal P.
The Journal of Biological Chemistry 2005 Feb; 280(7):5350.
Application:WB, Mouse, MEFs.
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Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2.
Cunnick JM, Mei L, Doupnik CA, Wu J.
The Journal of Biological Chemistry 2001 Jun; 276(26):24380.
Application:WB-Tr, Monkey, COS-7 cells.
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Activation of Gab1 in pancreatic acinar cells: effects of gastrointestinal growth factors/hormones on stimulation, phosphospecific phosphorylation, translocation and interaction with downstream signaling molecules.
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