HDAC1 (phospho S421/S423) polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of HDAC1.
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding S421/S423 of human HDAC1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
ELISA (1:4000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 20 mM PBS, 0.15 M NaCl, pH 7.2 (0.01% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from HeLa cells.
Lane 1 : HDAC1 (phospho Ser421/423) polyclonal antibody (Cat # PAB16973).
Lane 2 : Using the same antibody preincubated with synthesized peptide.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using HDAC1 (phospho Ser421/423) polyclonal antibody (Cat # PAB16973).Enzyme-linked Immunoabsorbent Assay
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Gene Info — HDAC1
Entrez GeneID
3065Protein Accession#
Q13547Gene Name
HDAC1
Gene Alias
DKFZp686H12203, GON-10, HD1, RPD3, RPD3L1
Gene Description
histone deacetylase 1
Omim ID
601241Gene Ontology
HyperlinkGene Summary
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq
Other Designations
OTTHUMP00000008745|reduced potassium dependency, yeast homolog-like 1
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Interactome
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Pathway
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Disease
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Publication Reference
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The subcellular distribution of HDAC1 in neurotoxic conditions is dependent on serine phosphorylation.
Zhu Y, Vidaurre OG, Adula KP, Kezunovic N, Wentling M, Huntley GW, Casaccia P.
Journal of Neuroscience 2017 Jun; 37(31):7547.
Application:WB-Tr, WB-Ti, Human, Rat, HEK 293 cells, Rat hippocampal neurons.
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The subcellular distribution of HDAC1 in neurotoxic conditions is dependent on serine phosphorylation.
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