APP polyclonal antibody
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
-
Specifications
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of APP.
Immunogen
A synthetic peptide corresponding to N-terminus 18 amino acids of human APP.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Western Blot (Tissue lysate)
Western blot analysis of APP in mouse brain tissue lysate with APP polyclonal antibody (Cat # PAB16733) at (A) 1 and (B) 2 ug/mL .Immunohistochemistry
Immunohistochemistry of APP in mouse brain tissue with APP polyclonal antibody (Cat # PAB16733) at 2.5 ug/mL .Enzyme-linked Immunoabsorbent Assay
-
Gene Info — APP
Entrez GeneID
351Protein Accession#
P05067Gene Name
APP
Gene Alias
AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN2
Gene Description
amyloid beta (A4) precursor protein
Gene Ontology
HyperlinkGene Summary
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq
Other Designations
A4 amyloid protein|amyloid beta A4 protein|amyloid-beta protein|beta-amyloid peptide|cerebral vascular amyloid peptide|peptidase nexin-II|protease nexin-II
-
Interactomes
-
Diseases
-
Publication Reference
-
APP binds DR6 to trigger axon pruning and neuron death via distinct caspases.
Nikolaev A, McLaughlin T, O'Leary DD, Tessier-Lavigne M.
Nature 2009 Feb; 457(7232):981.
-
Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease.
Selkoe DJ.
Annual Review of Cell Biology 1994 Jan; 10:373.
Application:IHC, WB, Human, Human brains.
-
A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors.
Ponte P, Gonzalez-DeWhitt P, Schilling J, Miller J, Hsu D, Greenberg B, Davis K, Wallace W, Lieberburg I, Fuller F.
Nature 1988 Feb; 331(6156):525.
-
APP binds DR6 to trigger axon pruning and neuron death via distinct caspases.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com