ATM (phospho S1981) polyclonal antibody
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More Files
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Specifications
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of ATM.
Immunogen
Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S1981 of human ATM.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Recommend Usage
Dot Blot (1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Dot Blot (Peptide)
Dot blot analysis of ATM (phospho S1981) polyclonal antibody (Cat # PAB1656) on nitrocellulose membrane. 50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. -
Gene Info — ATM
Entrez GeneID
472Protein Accession#
NP_000042;Q13315Gene Name
ATM
Gene Alias
AT1, ATA, ATC, ATD, ATDC, ATE, DKFZp781A0353, MGC74674, TEL1, TELO1
Gene Description
ataxia telangiectasia mutated
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
AT mutated|TEL1, telomere maintenance 1, homolog|ataxia telangiectasia mutated (includes complementation groups A, C and D)|ataxia telangiectasia mutated protein|human phosphatidylinositol 3-kinase homolog|serine-protein kinase ATM
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Interactomes
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Pathways
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Diseases
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Publication Reference
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ATM germline mutations in Spanish early-onset breast cancer patients negative for BRCA1/BRCA2 mutations.
Brunet J, Gutierrez-Enriquez S, Torres A, Berez V, Sanjose S, Galceran J, Izquierdo A, Menendez JA, Guma J, Borras J.
Clinical Genetics 2008 Apr; 73(5):465.
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Functional interaction between FOXO3a and ATM regulates DNA damage response.
Tsai WB, Chung YM, Takahashi Y, Xu Z, Hu MC.
Nature Cell Biology 2008 Apr; 10(4):460.
Application:Flow Cyt, IF, WB-Ce, Human, HEK 293T, MCF-7 cells.
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ATM germline mutations in Spanish early-onset breast cancer patients negative for BRCA1/BRCA2 mutations.
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