S1PR1 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of S1PR1 in mouse thymus lysate with S1PR1 polyclonal antibody (Cat # PAB16552) at (Lane 1) 1 and (Lane 2) 2 ug/mL .
Immunohistochemistry
Immunohistochemistry of S1PR1 in mouse thymus tissue with S1PR1 polyclonal antibody (Cat # PAB16552) at 5 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of S1PR1.
Immunogen
A synthetic peptide corresponding to C-terminus 14 amino acids of human S1PR1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of S1PR1 in mouse thymus lysate with S1PR1 polyclonal antibody (Cat # PAB16552) at (Lane 1) 1 and (Lane 2) 2 ug/mL .Immunohistochemistry
Immunohistochemistry of S1PR1 in mouse thymus tissue with S1PR1 polyclonal antibody (Cat # PAB16552) at 5 ug/mL .Enzyme-linked Immunoabsorbent Assay
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Gene Info — S1PR1
Entrez GeneID
1901Protein Accession#
NP_001391Gene Name
S1PR1
Gene Alias
CHEDG1, D1S3362, ECGF1, EDG-1, EDG1, FLJ58121, S1P1
Gene Description
sphingosine-1-phosphate receptor 1
Omim ID
601974Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. [provided by RefSeq
Other Designations
G protein-coupled sphingolipid receptor|OTTHUMP00000012525|endothelial differentiation, sphingolipid G-protein-coupled receptor, 1|sphingosine 1-phosphate receptor EDG1
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Interactome
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Pathway
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Disease
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Publication Reference
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S1PR3 is essential for phosphorylated fingolimod to protect astrocytes against oxygen-glucose deprivation-induced neuroinflammation via inhibiting TLR2/4-NFκB signalling.
Dong YF, Guo RB, Ji J, Cao LL, Zhang L, Chen ZZ, Huang JY, Wu J, Lu J, Sun XL.
Journal of Cellular and Molecular Medicine 2018 Jun; 22(6):3159.
Application：WB, Rat, Rat astrocytes.
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S1P1 receptor signaling overrides retention mediated by G alpha i-coupled receptors to promote T cell egress.
Pham TH, Okada T, Matloubian M, Lo CG, Cyster JG.
Immunity 2008 Jan; 28(1):122.
Application：Flow Cyt, Mouse, Mouse T cells.
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The sphingosine 1-phosphate receptor 1 causes tissue retention by inhibiting the entry of peripheral tissue T lymphocytes into afferent lymphatics.
Ledgerwood LG, Lal G, Zhang N, Garin A, Esses SJ, Ginhoux F, Merad M, Peche H, Lira SA, Ding Y, Yang Y, He X, Schuchman EH, Allende ML, Ochando JC, Bromberg JS.
Nature Immunology 2008 Jan; 9(1):42.
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Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists.
Mandala S, Hajdu R, Bergstrom J, Quackenbush E, Xie J, Milligan J, Thornton R, Shei GJ, Card D, Keohane C, Rosenbach M, Hale J, Lynch CL, Rupprecht K, Parsons W, Rosen H.
Science 2002 Apr; 296(5566):346.
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S1PR3 is essential for phosphorylated fingolimod to protect astrocytes against oxygen-glucose deprivation-induced neuroinflammation via inhibiting TLR2/4-NFκB signalling.
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