ACVR1 polyclonal antibody
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More Files
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Western Blot (Tissue lysate)
Western blot analysis of ACVR1 in human kidney tissue lysate with ACVR1 polyclonal antibody (Cat # PAB16548) at 1 ug/mL in (Lane 1) the absence and (Lane 2) the presence of blocking peptide.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ACVR1.
Immunogen
A synthetic peptide corresponding to C-terminus 14 amino acids of human ACVR1.
Host
Rabbit
Reactivity
Human, Mouse
Specificity
Specific of ACVR1B antibody.
Form
Liquid
Recommend Usage
Western Blot (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of ACVR1 in human kidney tissue lysate with ACVR1 polyclonal antibody (Cat # PAB16548) at 1 ug/mL in (Lane 1) the absence and (Lane 2) the presence of blocking peptide.Enzyme-linked Immunoabsorbent Assay
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Gene Info — ACVR1
Entrez GeneID
90Protein Accession#
NP_001096Gene Name
ACVR1
Gene Alias
ACTRI, ACVR1A, ACVRLK2, ALK2, FOP, SKR1, TSRI
Gene Description
activin A receptor, type I
Gene Ontology
HyperlinkGene Summary
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq
Other Designations
TGF-B superfamily receptor type I|activin A receptor, type II-like kinase 2|activin A type I receptor|hydroxyalkyl-protein kinase|serine/threonine-protein kinase receptor R1
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Interactome
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Pathway
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Disease
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Publication Reference
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Activin isoforms signal through type I receptor serine/threonine kinase ALK7.
Tsuchida K, Nakatani M, Yamakawa N, Hashimoto O, Hasegawa Y, Sugino H.
Molecular and Cellular Endocrinology 2004 May; 220(1-2):59.
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The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development.
Reissmann E, Jornvall H, Blokzijl A, Andersson O, Chang C, Minchiotti G, Persico MG, Ibanez CF, Brivanlou AH.
Genes Dev 2001 Aug; 15(15):2010.
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Molecular cloning of a novel type I receptor serine/threonine kinase for the TGF beta superfamily from rat brain.
Tsuchida K, Sawchenko PE, Nishikawa S, Vale WW.
Molecular and Cellular Neurosciences 1199 Jun; 7(6):467.
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Activin isoforms signal through type I receptor serine/threonine kinase ALK7.
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