BACE1 polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical (Formalin/PFA-fixed paraffin-embedded sections) staining in human pancreas with BACE1 polyclonal antibody (Cat # PAB16485).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of BACE1.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to human BACE1.
Host
Rabbit
Reactivity
Bovine, Dog, Guinea pig, Hamster, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat
Specificity
Internal domain of human.
Form
Liquid
Purification
Immunoaffinity purification
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (2.5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical (Formalin/PFA-fixed paraffin-embedded sections) staining in human pancreas with BACE1 polyclonal antibody (Cat # PAB16485). -
Gene Info — BACE1
Entrez GeneID
23621Protein Accession#
P56817Gene Name
BACE1
Gene Alias
ASP2, BACE, FLJ90568, HSPC104, KIAA1149
Gene Description
beta-site APP-cleaving enzyme 1
Omim ID
604252Gene Ontology
HyperlinkGene Summary
Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq
Other Designations
APP beta-secretase|aspartyl protease 2|beta-secretase|beta-site amyloid beta A4 precursor protein-cleaving enzyme|beta-site amyloid precursor protein cleaving enzyme|memapsin-2|membrane-associated aspartic protease 2|transmembrane aspartic proteinase Asp2
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Interactome
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Disease
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