SNAI2 (phospho S155/S158/S160/Y164/Y169) polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of SNAI2.
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding S155/S158/S160/Y164/Y169 of human SNAI2.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
ELISA (1:2000-1:5000)
Western Blot (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (50% glycerol, 0.01% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Enzyme-linked Immunoabsorbent Assay
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Gene Info — SNAI2
Entrez GeneID
6591Gene Name
SNAI2
Gene Alias
MGC10182, SLUG, SLUGH1, WS2D
Gene Description
snail homolog 2 (Drosophila)
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. [provided by RefSeq
Other Designations
OTTHUMP00000195093|neural crest transcription factor SLUG|slug (chicken homolog), zinc finger protein|slug homolog, zinc finger protein|snail 2
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Interactome
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Pathway
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Disease
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Publication Reference
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Snail2 cooperates with Snail1 in the repression of vitamin D receptor in colon cancer.
Larriba MJ, Martin-Villar E, Garcia JM, Pereira F, Pena C, de Herreros AG, Bonilla F, Munoz A.
Carcinogenesis 2009 Jun; 30(8):1459.
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p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug.
Wang SP, Wang WL, Chang YL, Wu CT, Chao YC, Kao SH, Yuan A, Lin CW, Yang SC, Chan WK, Li KC, Hong TM, Yang PC.
Nature Cell Biology 2009 May; 11(6):694.
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Requirement of the Akt/beta-catenin pathway for uterine carcinosarcoma genesis, modulating E-cadherin expression through the transactivation of slug.
Saegusa M, Hashimura M, Kuwata T, Okayasu I.
The American Journal of Pathology 2009 Apr; 174(6):2107.
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Snail2 cooperates with Snail1 in the repression of vitamin D receptor in colon cancer.
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