LDLR polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of LDLR.
Immunogen
A synthetic peptide corresponding to amino acids 500-550 of human LDLR.
Host
Rabbit
Reactivity
Human, Mouse, Primates
Specificity
This is specific to both the unglycosylated and glycosylated forms of the LDL Receptor. Immunogen has 100% homology with monkey and 92% homology with mouse. This antibody is useful for Western blot, where bands are seen ~95 KDa and ~160 KDa representing the unglycosylated and glycosylated forms of the LDL receptor, respectively.
Form
Liquid
Recommend Usage
Western Blot (0.5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (30% glycerol, 0.09% sodium azide)
Storage Instruction
Store at 4°C for short term. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot of HepG2 whole cell lysate with LDLR polyclonal antibody (Cat # PAB15520). -
Gene Info — LDLR
Entrez GeneID
3949Protein Accession#
P01130Gene Name
LDLR
Gene Alias
FH, FHC
Gene Description
low density lipoprotein receptor
Gene Ontology
HyperlinkGene Summary
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. [provided by RefSeq
Other Designations
LDL receptor|low-density lipoprotein receptor class A domain-containing protein 3
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Publication Reference
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Oxygen-independent disulfide bond formation in VEGF-A and CA9.
Fiana Levitin, Sandy Che-Eun Serena Lee, Stephanie Hulme, Ryan A Rumantir, Amy S Wong, Marmendia R Meester, Marianne Koritzinsky.
The Journal of Biological Chemistry 2021 Mar; 296:100505.
Application:IP, WB-Tr, Human, HeLa cells.
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Hepatitis C virus and other flaviviridae viruses enter cells via low density lipoprotein receptor.
Agnello V, Abel G, Elfahal M, Knight GB, Zhang QX.
PNAS 1999 Oct; 96(22):12766.
Application:IF, Func, Human, BT, G4, HepG2, MRC-5 cells.
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The low density lipoprotein receptor. Identification of amino acids in cytoplasmic domain required for rapid endocytosis.
Davis CG, van Driel IR, Russell DW, Brown MS, Goldstein JL.
The Journal of Biological Chemistry 1987 Mar; 262(9):4075.
Application:IP, RIA, Hamster, ldlA-7 cells.
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Oxygen-independent disulfide bond formation in VEGF-A and CA9.
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