TCF7L2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TCF7L2.
Immunogen
A synthetic peptide corresponding to amino acids 150-200 of human TCF7L2.
Host
Rabbit
Reactivity
Bovine, Human, Mouse
Specificity
Immunogen has 93% homology to mouse and bovine proteins. This antibody is useful for Western blot, where a band is seen ~55 KDa.
Form
Liquid
Recommend Usage
Western Blot (0.5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (30% glycerol, 0.09% sodium azide)
Storage Instruction
Store at 4°C for short term. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot of Jurkat cell lysate with TCF7L2 polyclonal antibody (Cat # PAB15508). -
Gene Info — TCF7L2
Entrez GeneID
6934Protein Accession#
Q9NQB0Gene Name
TCF7L2
Gene Alias
TCF-4, TCF4
Gene Description
transcription factor 7-like 2 (T-cell specific, HMG-box)
Gene Ontology
HyperlinkGene Summary
This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes
Other Designations
OTTHUMP00000020496|transcription factor 7-like 2
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Interactome
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Pathway
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Disease
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Publication Reference
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TCF-4 binds beta-catenin and is expressed in distinct regions of the embryonic brain and limbs.
Cho EA, Dressler GR.
Mechanisms of Development 1998 Sep; 77(1):9.
Application:IF, Mouse, Monkey, COS, NIH/3T3 cells.
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Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4.
Korinek V, Barker N, Moerer P, van Donselaar E, Huls G, Peters PJ, Clevers H.
Nature Genetics 1998 Aug; 19(4):379.
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TCF-4 binds beta-catenin and is expressed in distinct regions of the embryonic brain and limbs.
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