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Last updated: 2014/11/23
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TLR4 polyclonal antibody

  • Catalog # : PAB15432
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of TLR4.
  • Immunogen:
  • A synthetic peptide corresponding to amino acids 420-435 of human TLR4.
  • Host:
  • Rabbit
  • Reactivity:
  • Human, Mouse
  • Specificity:
  • Detects ~75-80KDa when tested against partial recombinant mouse TLR4 (extra-cellular portion plus His-tag).
  • Form:
  • Liquid
  • Recommend Usage:
  • Western Blot (1-3 ug/mL)
    Immunohistochemistry (1:50)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.05% BSA, sodium azide)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Recombinant protein)
  • Western Blot (Recombinant protein)
  • Western blot analysis of recombinant TLR4 protein with TLR4 polyclonal antibody (Cat # PAB15432).
  • Immunohistochemistry
  • Immunohistochemistry
  • Immunochemical staining of mouse spleen tissue (A, B) and mouse colitis colon (C) with TLR4 polyclonal antibody (Cat # PAB15432).
  • Immunocytochemistry
  • Flow Cytometry
  • Application Image
  • Western Blot (Recombinant protein)
  • Western Blot (Recombinant protein)
  • enlarge
  • Immunocytochemistry
  • Flow Cytometry
  • Gene Information
  • Entrez GeneID:
  • 7099
  • Gene Name:
  • TLR4
  • Gene Alias:
  • ARMD10,CD284,TOLL,hToll
  • Gene Description:
  • toll-like receptor 4
  • Gene Summary:
  • The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. It has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Also, several transcript variants of this gene have been found, but the protein coding potential of most of them is uncertain. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000022807,homolog of Drosophila toll
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