INS polyclonal antibody
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
-
Specification
Product Description
Rabbit polyclonal antibody raised against INS.
Immunogen
Human INS.
Host
Rabbit
Reactivity
Human, Pig
Form
Liquid
Recommend Usage
Immunohistochemistry (1:50-1:100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (1% BSA, 0.05% sodium azide)
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry (Frozen sections)
Immunocytochemistry
-
Gene Info — INS
Entrez GeneID
3630Gene Name
INS
Gene Alias
ILPR, IRDN
Gene Description
insulin
Gene Ontology
HyperlinkGene Summary
After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds. Binding of this mature form of insulin to the insulin receptor (INSR) stimulates glucose uptake. A variety of mutant alleles with changes in the coding region have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. [provided by RefSeq
Other Designations
OTTHUMP00000011161|OTTHUMP00000011162|OTTHUMP00000196038|proinsulin
-
Interactome
-
Pathway
-
Disease
-
Publication Reference
-
ICA512 signaling enhances pancreatic beta-cell proliferation by regulating cyclins D through STATs.
Mziaut H, Kersting S, Knoch KP, Fan WH, Trajkovski M, Erdmann K, Bergert H, Ehehalt F, Saeger HD, Solimena M.
PNAS 2008 Jan; 105(2):674.
Application:IHC-P, WB-Ce, Mice, rat, Mice pancreas, INS-1 cells.
-
R-type Ca(2+)-channel-evoked CICR regulates glucose-induced somatostatin secretion.
Zhang Q, Bengtsson M, Partridge C, Salehi A, Braun M, Cox R, Eliasson L, Johnson PR, Renstrom E, Schneider T, Berggren PO, Gopel S, Ashcroft FM, Rorsman P.
Nature Cell Biology 2007 Apr; 9(4):453.
Application:IF, Mouse, Mouse pancreatic δ-cells.
-
Hyperinsulinemic hypoglycemia in adults with islet-cell hyperplasia and degranulation of exocrine cells of the pancreas.
Weidenheim KM, Hinchey WW, Campbell WG Jr.
American Journal of Clinical Pathology 1983 Jan; 79(1):14.
-
ICA512 signaling enhances pancreatic beta-cell proliferation by regulating cyclins D through STATs.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com