CD14 polyclonal antibody
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Specifications
Product Description
Rabbit polyclonal antibody raised against recombinant CD14.
Immunogen
Recombinant protein corresponding to human CD14.
Host
Rabbit
Reactivity
Human, Mouse
Specificity
The antiserum represents a marker for human CD14. The CD14 glycoprotein, gp 55, is present on most monocytic and macrophages like cell types: monocytes, macrophages, Kupffer cells, pleural phagocytic cells and dendritic reticular cells. CD14 is also observed on granulocytes and activated or transformed B-cells. Furthermore CD14 is present in a soluble form in human serum, urine and other body fluids. The CD14 molecule has been reported to be a receptor for endotoxin.
Form
Lyophilized
Recommend Usage
Flow Cytometry (1:100-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from PBS
Storage Instruction
Store at -80°C on dry atmosphere.
Aliquot to avoid repeated freezing and thawing. -
Applications
Immunoprecipitation
Flow Cytometry
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Gene Info — CD14
Entrez GeneID
929Gene Name
CD14
Gene Alias
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Gene Description
CD14 molecule
Omim ID
158120Gene Ontology
HyperlinkGene Summary
CD14 is a surface protein preferentially expressed on monocytes/macrophages. It binds lipopolysaccharide binding protein and recently has been shown to bind apoptotic cells. Alternative splicing results in multiple transcript variants encoding the same isoform. [provided by RefSeq
Other Designations
CD14 antigen|monocyte differentiation antigen CD14
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Interactomes
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Pathways
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Diseases
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Publication Reference
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Monocytic thrombomodulin triggers LPS- and gram-negative bacteria-induced inflammatory response.
Ma CY, Shi GY, Shi CS, Kao YC, Lin SW, Wu HL.
Journal of Immunology 2012 Jun; 188(12):6328.
Application:IF, IP, WB, Mouse, Mouse macrophages.
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LPS-binding protein and CD14-dependent attachment of hepatitis B surface antigen to monocytes is determined by the phospholipid moiety of the particles.
Vanlandschoot P, Van Houtte F, Roobrouck A, Farhoudi A, Stelter F, Peterson DL, Gomez-Gutierrez J, Gavilanes F, Leroux-Roels G.
The Journal of General Virology 2002 Sep; 83(Pt 9):2279.
Application:Flow Cyt, Func, Human, PBMCs.
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Human lactoferrin interacts with soluble CD14 and inhibits expression of endothelial adhesion molecules, E-selectin and ICAM-1, induced by the CD14-lipopolysaccharide complex.
Baveye S, Elass E, Fernig DG, Blanquart C, Mazurier J, Legrand D.
Infection and Immunity 2000 Dec; 68(12):6519.
Application:WB-Re, Recombinant proteins.
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Monocytic thrombomodulin triggers LPS- and gram-negative bacteria-induced inflammatory response.
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