LCK (phospho Y505) polyclonal antibody
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More Files
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Western Blot (Cell lysate)
Western blot analysis of extracts from JK cells using LCK (phospho Y505) polyclonal antibody (Cat # PAB14161).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of LCK.
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding Y505 of human LCK.
Sequence
GQYpQP
Host
Rabbit
Theoretical MW (kDa)
56
Reactivity
Human, Mouse, Rat
Form
Liquid
Purification
Immunoaffinity purification
Concentration
1 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (without Mg2+ and Ca2+), 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from JK cells using LCK (phospho Y505) polyclonal antibody (Cat # PAB14161). -
Gene Info — LCK
Entrez GeneID
3932Protein Accession#
P06239Gene Name
LCK
Gene Alias
YT16, p56lck, pp58lck
Gene Description
lymphocyte-specific protein tyrosine kinase
Omim ID
153390Gene Ontology
HyperlinkGene Summary
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described. [provided by RefSeq
Other Designations
T-lymphocyte specific protein tyrosine kinase p56lck|p56(LSTRA) protein-tyrosine kinase|protein tyrosine kinase|proto-oncogene tyrosine-protein kinase LCK
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Interactome
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Pathway
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Disease
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Publication Reference
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Growth transformation of human T cells by herpesvirus saimiri requires multiple Tip-Lck interaction motifs.
Heck E, Friedrich U, Gack MU, Lengenfelder D, Schmidt M, Muller-Fleckenstein I, Fleckenstein B, Ensser A, Biesinger B.
Journal of Virology 2006 Oct; 80(20):9934.
Application：WB-Ce, Monkey, Human, COS-7 cells, Monkey T cells, Jurkat clone E6-1 cells.
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Hsp90 is essential for the synthesis and subsequent membrane association, but not the maintenance, of the Src-kinase p56(lck).
Bijlmakers MJ, Marsh M.
Molecular Biology of the Cell 2000 May; 11(5):1585.
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Growth transformation of human T cells by herpesvirus saimiri requires multiple Tip-Lck interaction motifs.
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