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Last updated: 2014/12/14
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TOP2A polyclonal antibody

  • Catalog # : PAB13698
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of TOP2A.
  • Immunogen:
  • A synthetic peptide corresponding to amino acids 1513-1530 of human TOP2A.
  • Sequence:
  • RAKKPIKYLEESDEDDLF
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Specificity:
  • Recognizes a 170 KDa protein identified as Topoisomerase IIalpha.
  • Form:
  • Liquid
  • Recommend Usage:
  • Western Blot (5-10 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In 10 mM PBS, pH 7.4 (0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot
  • Immunohistochemistry
  • Immunofluorescence
  • Immunoprecipitation
  • Immunoprecipitation
  • Immunoprecipitation (Native & denatured) with TOP2A polyclonal antibody (Cat # PAB13698). Use Protein A. Use 10 ug/mg Raji cell lysate.
  • Application Image
  • Western Blot
  • Immunohistochemistry
  • Immunofluorescence
  • Gene Information
  • Entrez GeneID:
  • 7153
  • Gene Name:
  • TOP2A
  • Gene Alias:
  • TOP2,TP2A
  • Gene Description:
  • topoisomerase (DNA) II alpha 170kDa
  • Gene Summary:
  • This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromsome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq
  • Other Designations:
  • DNA topoisomerase II, 170 kD,DNA topoisomerase II, alpha isozyme,topoisomerase (DNA) II alpha (170kD)
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