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Last updated: 2014/9/15
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CASP8 polyclonal antibody

  • Catalog # : PAB13681
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of CASP8.
  • Immunogen:
  • A synthetic peptide corresponding to amino acids at internal region of human CASP8.
  • Host:
  • Rabbit
  • Theoretical MW (kDa):
  • 55.3
  • Reactivity:
  • Human, Mouse, Rat
  • Specificity:
  • Different to the related mouse sequence by a single amino acids.
  • Form:
  • Lyophilized
  • Purification:
  • Affinity purification
  • Recommend Usage:
  • Western Blot (1 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • Lyophilized from 0.9 mg NaCl, 0.2 mg Na2HPO4 (5 mg BSA, 0.05 mg sodium azide, 0.05 mg Thimerosal)
  • Storage Instruction:
  • Store at -20°C on dry atmosphere.
    After reconstitution with 200 uL of deionized water and concentration will be 500 ug/mL, store at -20°C or lower.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide and thimerosal: POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot
  • Western Blot
  • Western blot analysis of cell and tissue lysates with CASP8 polyclonal antibody (Cat # PAB13681).
    Lane 1 : Rat thymus tissue.
    Lane 2 : Rat liver tissue.
    Lane 3 : MCF-7.
    Lane 4 : HeLa.
    Lane 5 : Smmc.
    Lane 6 : Jurkat.
    Lane 7 : Colo 320.
  • Application Image
  • Gene Information
  • Entrez GeneID:
  • 841
  • Gene Name:
  • CASP8
  • Gene Alias:
  • ALPS2B,CAP4,FLICE,FLJ17672,MACH,MCH5,MGC78473
  • Gene Description:
  • caspase 8, apoptosis-related cysteine peptidase
  • Gene Summary:
  • This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq
  • Other Designations:
  • FADD-homologous ICE/CED-3-like protease,MACH-alpha-1/2/3 protein,MACH-beta-1/2/3/4 protein,Mch5 isoform alpha,OTTHUMP00000163718,OTTHUMP00000163719,OTTHUMP00000163720,caspase 8,caspase 8, apoptosis-related cysteine protease,cysteine protease,procaspase-8
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