CAV3 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
CAV3 polyclonal antibody (Cat # PAB13676) (0.3 ug/mL) staining of human heart lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
CAV3 polyclonal antibody (Cat # PAB13676) (3.8 ug/mL) staining of paraffin embedded human skeletal muscle. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of CAV3.
Immunogen
A synthetic peptide corresponding to N-terminus of human CAV3.
Sequence
EHTDLEAQIVKDIH-C
Host
Goat
Theoretical MW (kDa)
17.3
Reactivity
Human, Mouse, Rat
Specificity
Reported variants represent identical protein (NP_001225.1; NP_203123.1).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:4000)
Western Blot (0.3-1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (3-5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 0.5 mg/mL Tris saline, pH 7.3 (0.02% sodium azide, 0.5% BSA)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
CAV3 polyclonal antibody (Cat # PAB13676) (0.3 ug/mL) staining of human heart lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
CAV3 polyclonal antibody (Cat # PAB13676) (3.8 ug/mL) staining of paraffin embedded human skeletal muscle. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — CAV3
Entrez GeneID
859Protein Accession#
NP_203123.1Gene Name
CAV3
Gene Alias
LGMD1C, LQT9, MGC126100, MGC126101, MGC126129, VIP-21, VIP21
Gene Description
caveolin 3
Gene Ontology
HyperlinkGene Summary
This gene encodes a caveolin family member, which functions as a component of the caveolae plasma membranes found in most cell types. Caveolin proteins are proposed to be scaffolding proteins for organizing and concentrating certain caveolin-interacting molecules. Mutations identified in this gene lead to interference with protein oligomerization or intra-cellular routing, disrupting caveolae formation and resulting in Limb-Girdle muscular dystrophy type-1C (LGMD-1C), hyperCKemia or rippling muscle disease (RMD). Alternative splicing has been identified for this locus, with inclusion or exclusion of a differentially spliced intron. In addition, transcripts utilize multiple polyA sites and contain two potential translation initiation sites. [provided by RefSeq
Other Designations
M-caveolin
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Interactome
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Pathway
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Disease
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Publication Reference
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Mechanistic insights into δ-opioid-induced cardioprotection: Involvement of caveolin translocation to the mitochondria.
Wang JW, Xue ZY, Wu AS.
Life Sciences 2019 Nov; 247:116942.
Application：WB, Mouse, Mouse ventricle-purified mitochondria.
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Caveolin-3 is a sensitive and specific marker for rhabdomyosarcoma.
Fine SW, Lisanti MP, Argani P, Li M.
Applied Immunohistochemistry & Molecular Morphology 2005 Sep; 13(3):231.
Application：IHC-P, Human, Cardiac myocytes, Skeletal muscle.
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Mechanistic insights into δ-opioid-induced cardioprotection: Involvement of caveolin translocation to the mitochondria.
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